PXD056695 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nanomaterials trigger functional responses in primary human immune cells |
| Description | Targeting the immune system with nanoparticles (NPs) to deliver immunomodulatory molecules emerged as a solution to address intra-tumoral immunosuppression and enhance therapeutic response. While the potential of nanoimmunotherapies in reactivating immune cells has been evaluated in several preclinical studies, the impact of drug-free nanomaterials on the immune system remains unknown. Here, we characterize the molecular and functional response of human NK cells and pan T cells to a selection of five NPs that are commonly developed for biomedical applications. After a pre-screen to evaluate the toxicity of these nanomaterials on immune cells, we selected ultrasmall silica-based gadolinium (Si-Gd) NPs and poly(lactic-co-glycolic acid) (PLGA) NPs for further investigation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-10-27 |
| AnnouncementXML | Submission_2025-10-26_18:25:23.925.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD056695 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Francois Delalande |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-10-10 08:01:11 | ID requested | |
| ⏵ 1 | 2025-10-26 18:25:24 | announced | |
Publication List
| 10.1002/advs.202505729; |
| 10.6019/PXD056695; |
| Mittelheisser V, Lefebvre O, Banerjee M, Ghosh S, Dupas A, Diringer MC, Blumberger J, Bochler L, Harlepp S, Larnicol A, Pichot A, Stemmelen T, Molitor A, Moritz C, Carapito C, Carapito R, Charbonni, è, re LJ, Lux F, Tillement O, Goetz JG, Detappe A, Nanomaterials Trigger Functional Anti-Tumoral Responses in Primary Human Immune Cells. Adv Sci (Weinh), 12(39):e05729(2025) [pubmed] |
Keyword List
| submitter keyword: Nanomaterials |
| Human Lymphocytes |
| nLC-MS/MS |
| SP3-SPE |
| Differential analysis |
Contact List
| Christine Carapito |
|---|
| contact affiliation | CNRS, UMR7178, LSMBO, 67087 Strasbourg, FRANCE Université de Strasbourg, IPHC, 25 rue Becquerel, 67087 Strasbourg, FRANCE |
| contact email | ccarapito@unistra.fr |
| lab head | |
| Francois Delalande |
|---|
| contact affiliation | CNRS |
| contact email | delaland@unistra.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD056695
- Label: PRIDE project
- Name: Nanomaterials trigger functional responses in primary human immune cells
