PXD056684-1

PXD056684 is an original dataset announced via ProteomeXchange.

Title	Pig myocardial tissue quantitative proteomics
Description	Proteomics study of the anthracycline-induced cardiotoxicity in in pigs with pre-existing left ventricular (LV) pressure overload. Large White pigs (2-month-old males and females) were used to induce LV pressure overload via supravalvular aortic stenosis (or sham operation). After 4 months, animals were subsequently exposed to low-risk cumulative doses of anthracyclines (doxorubicin, 5 weekly 1 mg/kg intravenous injections) or vehicle. A total of 16 pigs were divided in four groups: (1) healthy controls (no LV overload or anthracyclines), (2) Doxorubicin (Dox, no LV overload but anthracyclines), (3) Banding (LV overload without anthracyclines), and (4) Banding+Doxorubicin (LV overload plus anthracyclines). A high-throughput quantitative proteomic analysis was performed in myocardial tissue.
HostingRepository	PRIDE
AnnounceDate	2026-02-05
AnnouncementXML	Submission_2026-02-04_23:29:13.043.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Inmaculada Jorge
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: NEWT:9825;
ModificationList	methylthiolated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-10 03:33:57	ID requested
⏵ 1	2026-02-04 23:29:14	announced

Gal, á, n-Arriola C, P, é, rez-Camargo D, Jorge I, Bautista V, Ayaon-Albarr, á, n A, P, é, rez-Mart, í, nez C, de Molina-Iracheta A, C, á, diz L, Medina-Hern, á, ndez D, Caballero-Henares C, Lopez-Mart, í, n GJ, V, á, zquez J, Ochala J, Fuster V, S, á, nchez-Gonz, á, lez J, Ib, á, ñ, ez B, Anthracycline cardiotoxicity: role of metabolic vulnerability induced by cardiac pressure overload. Eur Heart J, ():(2026) [pubmed]

10.1093/eurheartj/ehaf1060;

submitter keyword: myocardial tissue, LC-MSMS, TMT10plex isobaric labeling, quantitative proteomics,Pig

Jesús María Vázquez Cobos
contact affiliation	Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid.
contact email	jvazquez@cnic.es
lab head
Inmaculada Jorge
contact affiliation	Cardiovascular Proteomics Lad. Spanish National Center for Cardiovascular Research (CNIC). Madrid.
contact email	ijorge@cnic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD056684

PRIDE project URI

• PRIDE
  1. PXD056684
     1. Label: PRIDE project
     2. Name: Pig myocardial tissue quantitative proteomics