PXD056664 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Muscle fiber proteomics reveals sex- and fiber type-specific adaptations to resistance training |
| Description | Skeletal muscle hypertrophy is a hallmark of resistance training that positively impacts health and longevity. However, despite physiological differences between sexes and fiber types, the underlying proteome changes with resistance training have not been studied in a sex- and fiber type-specific manner. Herein, we show sex differences in the fiber type-specific proteome, predominantly in type II fibers. Following 8 weeks of resistance training, substantial remodeling of the human skeletal muscle proteome occurred in a sex- and fiber type-specific manner. Notably, type II fibers exhibited much greater adaptations across both sexes, whereas the main sex-difference was a greater remodeling of intermediate filaments in females. In addition, baseline abundance of proteins involved in translation was highly correlated with fiber hypertrophy, and differed between sexes and fiber types. Thus, translational capacity may partially explain differences in resistance training-induced hypertrophy. Our findings demonstrate key aspects of sex- and fiber type differences in muscle physiology and their contributions to resistance training-induced adaptions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-10 |
| AnnouncementXML | Submission_2026-09-10_03:02:00.009.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Roger Moreno Justicia |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-10-09 13:01:45 | ID requested | |
| ⏵ 1 | 2026-09-10 03:02:00 | announced | |
Publication List
Keyword List
Contact List
| Atul Deshmukh |
|---|
| contact affiliation | University of Copenhagen, Novo Nordisk Center for Basic Metabolic Research |
| contact email | atul.deshmukh@sund.ku.dk |
| lab head | |
| Roger Moreno Justicia |
|---|
| contact affiliation | Novo Nordisk Foundation Center for Basic Metabolic Research |
| contact email | roger.moreno.justicia@sund.ku.dk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD056664 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD056664
- Label: PRIDE project
- Name: Muscle fiber proteomics reveals sex- and fiber type-specific adaptations to resistance training
