PXD056650-1

PXD056650 is an original dataset announced via ProteomeXchange.

Title	A m6A methyltransferase fine-tune m6A modification and ubiquitination to balance antiviral immunity and yield
Description	Posttranscriptional and posttranslational modifications play crucial roles in plant immunity. However, how plant fine-tune these two modifications to activate antiviral immunity remains unknown. Here, we report that the m6A methyltransferase TaHAKAI is utilized by wheat yellow mosaic virus (WYMV) to increase viral genomic m6A modification and promotes viral replication. However, TaHAKAI also functions as an E3 ligase that targets the viral RNA silencing suppressor P2 for degradation and inhibits viral infection. A major allele of TaHAKAI in susceptible cultivar reduced the E3 ligase activity but not m6A methyltransferase activity, promoting viral infection. Interestingly, TaHAKAIR attenuates the mRNA stability of TaWPS1, the negative regulator of spike development, to increase panicle length and spikelet number by modulating its m6A modification. Our study reveals a new mechanisms of balancing disease resistance and yield by fine-tuning m6A modification and ubiquitination.
HostingRepository	PRIDE
AnnounceDate	2024-10-09
AnnouncementXML	Submission_2024-10-09_08:54:25.547.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	俊 郭
SpeciesList	scientific name: Triticum aestivum (Wheat); NCBI TaxID: 4565;
ModificationList	ubiquitinylated lysine
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-09 04:23:19	ID requested
⏵ 1	2024-10-09 08:54:25	announced
2	2024-10-22 07:00:58	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: viral protein, Wheat yellow mosaic virus,m6A

Guo Jun
contact affiliation	State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Key Laboratory of Biotechnology in Plant Protection of MOA of China and Institute of Plant Virology, Ningbo University, Ningbo, 315211, China
contact email	18374954946@163.com
lab head
俊 郭
contact affiliation	Ningbo University
contact email	1009151437@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD056650
     1. Label: PRIDE project
     2. Name: A m6A methyltransferase fine-tune m6A modification and ubiquitination to balance antiviral immunity and yield