PXD056452-1

PXD056452 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Redox-dependent protein S-glutathionylation governs azacitidine sensitivity and resistance in AML
Description	Hypomethylation therapy significantly prolongs survival of patients with high-risk myelodysplastic syndrome progressing to acute myeloid leukaemia, yet most patients develop resistance. In this work we identified redox-regulated mechanisms of hypomethylation therapy and revealed that in resistant cells, hypomethylation therapy is failing to induce oxidative modifications of proteins. Modulation of redox homeostasis by targeting glutathione metabolism induces protein oxidation in resistant cells and overcomes chemoresistance.
HostingRepository	PRIDE
AnnounceDate	2026-01-12
AnnouncementXML	Submission_2026-01-11_16:28:45.362.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kristyna Gloc Pimkova
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-02 07:50:05	ID requested
⏵ 1	2026-01-11 16:28:46	announced

Publication List

10.1016/j.redox.2025.103958;
Nemes D, My, š, á, kov, á M, Mina, ř, í, k L, Jon, á, š, ov, á A, Stopka T, Pimkov, á KG, Redox-dependent protein S-glutathionylation governs azacitidine sensitivity and resistance in AML. Redox Biol, 89():103958(2026) [pubmed]

10.1016/j.redox.2025.103958;

Nemes D, My, š, á, kov, á M, Mina, ř, í, k L, Jon, á, š, ov, á A, Stopka T, Pimkov, á KG, Redox-dependent protein S-glutathionylation governs azacitidine sensitivity and resistance in AML. Redox Biol, 89():103958(2026) [pubmed]

Keyword List

submitter keyword: None

submitter keyword: None

Contact List

Kristyna Gloc
contact affiliation	BIOCEV, 1st Faculty of Medicine, Prague
contact email	kristyna.pimkova@lf1.cuni.cz
lab head
Kristyna Gloc Pimkova
contact affiliation	BIOCEV, 1st Medical Faculty, Charles University, Vestec, Czech Republic
contact email	kristyna.pimkova@lf1.cuni.cz
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD056452
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD056452

PRIDE project URI

Repository Record List

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