PXD056286-1

PXD056286 is an original dataset announced via ProteomeXchange.

Title	Complement profiling on sural nerves of patients with chronic inflammatory demyelinating polyneuropathy
Description	Overall, 55 sural nerve biopsies from patients with CIDP (n=36) and CIDP-variants (n=18) were included into the study. Immunohistochemical analysis of the sural nerve specimens showed an aberrant deposition of terminal complement complex C5b-9 on endoneural capillaries in 52 (94%) of patients in addition to endoneural CD8+ T cell- and CD68+ macrophage infiltration. Gene expression studies showed an increase of factors C3 and C6 compared to NDCs with no difference in regard to clinical phenotype, whereas levels of IL6 or TNF-alpha were not significantly elevated. Our proteomic profiling approach revealed the statistically significant dysregulation of 50 proteins, which based on their respective functions suggest altered mitochondrial activity, perturbed cytoskeleton, and increased oxidative stress. The majority of patients with high to moderate complement deposition presented with a progressive disease course, however without any correlation with disease severity as measured by INCAT or MRC at baseline and follow-up. Our combined data supports the role of complement in CIDP pathogenesis. Based on these findings, we propose to further evaluate complement inhibition therapies as new targeted treatment option for patients with CIDP.
HostingRepository	PRIDE
AnnounceDate	2025-09-29
AnnouncementXML	Submission_2025-09-28_17:53:17.034.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andreas Hentschel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-26 04:32:27	ID requested
⏵ 1	2025-09-28 17:53:17	announced

10.1007/s00401-025-02936-w;

Stascheit F, Roos A, Schroeter CB, Thomas JK, Hahn K, Pre, ß, ler H, Hentschel A, Schlotter-Weigel B, Schoser B, Ruck T, Meisel A, Stenzel W, Preusse C, Complement profiling of sural nerves in chronic-inflammatory demyelinating polyneuropathy. Acta Neuropathol, 150(1):32(2025) [pubmed]

submitter keyword: proteomics, gene expression,chronic inflammatory demyelinating polyneuropathy

complement profiles

sural nerve

Prof. Dr. Albert Sickmann
contact affiliation	Proteomics, Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany
contact email	Albert.Sickmann@isas.de
lab head
Andreas Hentschel
contact affiliation	Leibniz Institut für Analytische Wissenschaften
contact email	andreas.hentschel@isas.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD056286

PRIDE project URI

• PRIDE
  1. PXD056286
     1. Label: PRIDE project
     2. Name: Complement profiling on sural nerves of patients with chronic inflammatory demyelinating polyneuropathy