PXD056264-1
PXD056264 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Inhibition of osteosarcoma progression by sporoderm-removed ganoderma lucidum spores |
| Description | Osteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action. Our in vivo and in vitro experiments showed that RGLS significantly inhibited S-180 OS cell proliferation, colony formation, and migration, while simultaneously inducing apoptosis. Multi-omics analysis revealed that RGLS disrupted glycerophospholipid metabolism by upregulating lysophosphatidylcholine (LysoPC) levels through phospholipase A2 (PLA2)-mediated pathways. Co-culture assays further demonstrated that RGLS promoted the endocytosis of macrophage-derived Pla2g7 protein into S-180 cells, enhancing its anti-cancer effects. Additionally, RGLS modulated the cellular fatty acid profile and suppressed the β-oxidation of long-chain fatty acids, leading to energy depletion in OS cells. These findings provide a novel view of the multi-targeted mechanisms of RGLS, positioning it as a promising candidate for OS therapy. |
| HostingRepository | iProX |
| AnnounceDate | 2024-09-25 |
| AnnouncementXML | Submission_2024-09-25_19:00:59.479.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Mengyao Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-09-25 19:00:39 | ID requested | |
| ⏵ 1 | 2024-09-25 19:00:59 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Sporoderm-removed Ganoderma lucidum spores, Osteosarcoma |
Contact List
| Jihong Yang | |
|---|---|
| contact affiliation | BoYu Intelligent Health Innovation Laboratory |
| contact email | yangdataever@163.com |
| lab head | |
| Mengyao Wang | |
| contact affiliation | BoYu Intelligent Health Innovation Laboratory |
| contact email | wangmy2022@gmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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