PXD056111-1

PXD056111 is an original dataset announced via ProteomeXchange.

Title	Identification of Novel Paracrine Therapeutic Targets in Peritoneal Metastases through Integrative Proteotranscriptomic Analysis of Ascites
Description	The presence of ascites in peritoneal metastases (PM) portends a poor prognosis for all intra-abdominal malignancies. However, the molecular ligands within ascites and their biological relevance remain unclear. We report a comprehensive proteomics analysis of cell-free ascites in PM, including 160 malignant PM ascites covering a spectrum of 17 histological origins and 15 ascites of benign origin. This is the first large-scale proteomic analysis of cell-free ascites across diverse histological subsets of PM that can be harnessed for discovery of novel therapeutics and understanding of PM biology.
HostingRepository	iProX
AnnounceDate	2024-09-23
AnnouncementXML	Submission_2025-09-22_00:35:09.731.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chin-Ann Johnny Ong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-23 23:09:32	ID requested
⏵ 1	2025-09-22 00:35:10	announced

Dataset with its publication pending

submitter keyword: Peritoneal metastases, proteomics, fibrinolysis, PAI-1, S100A10, cancer, nanobody, single cell sequencing, novel therapeutics, coagulation

Chin-Ann Johnny Ong
contact affiliation	National Cancer Centre Singapore
contact email	johnny.ong.c.a@singhealth.com.sg
lab head
Chin-Ann Johnny Ong
contact affiliation	National Cancer Centre Singapore
contact email	johnny.ong.c.a@singhealth.com.sg
dataset submitter

iProX dataset URI