PXD056064 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | CIAA: Integrated Proteomics and Structural Modeling for Understanding Cysteine Reactivity with Iodoacetamide Alkyne |
| Description | This study utilizes cysteine chemoproteomics paired with a high-throughput structure-guided in silico approach towards assessing structural motifs of cysteines that are highly reactive towards iodoacetamide alkyne (IAA). |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-10-13 |
| AnnouncementXML | Submission_2025-10-12_16:18:00.847.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lisa Boatner |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | biotinylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-09-20 17:55:56 | ID requested | |
| ⏵ 1 | 2025-10-12 16:18:01 | announced | |
Publication List
| 10.1021/acschembio.5c00225; |
| Boatner LM, Eberhardt J, Shikwana F, Holcomb M, Lee P, Houk KN, Forli S, Backus KM, CIAA: Integrated Proteomics and Structural Modeling for Understanding Cysteine Reactivity with Iodoacetamide Alkyne. ACS Chem Biol, 20(7):1669-1682(2025) [pubmed] |
Keyword List
| submitter keyword: reactivity,cysteine, chemoproteomics, isoTOP-ABPP |
Contact List
| Keriann Marie Backus |
|---|
| contact affiliation | Biological Chemistry, UCLA, California, United States |
| contact email | kbackus@mednet.ucla.edu |
| lab head | |
| Lisa Boatner |
|---|
| contact affiliation | The University of California, Los Angeles |
| contact email | lisaboatner@g.ucla.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD056064 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD056064
- Label: PRIDE project
- Name: CIAA: Integrated Proteomics and Structural Modeling for Understanding Cysteine Reactivity with Iodoacetamide Alkyne
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