PXD056061 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Accelerated aging modulates the toxicological properties of the diazo tattoo pigment Po13 |
| Description | Pigment particles used in tattooing may exert long terms effect by releasing diffusible degradation products. In the present work, aqueous suspensions of the organic orange pigment Po13 were aged by exposure to simulated sunlight at 40°C. The morphology and the surface charge of Po13 particles were barely modified upon aging, but their size was reduced. Soluble photoproducts were detected in the liquid fractions. One of this photoproduct (DCBP) was produced in large amount in suspension in isopropanol and purified. The toxicological profiles of aged suspensions, their soluble fractions and DCBP were then determined on the keratinocyte cell line HaCaT. Impact of suspensions of Po13 on viability was hardly affected by aging. In contrast, the soluble fractions were more toxic after aging. Suspensions and filtrates induced neither release of reactive oxygen species nor formation of DNA strand breaks. The samples exhibited only limited effects on the proteome of HaCaT cells. Conversely, DCBP was cytotoxic and induced the production of ROS, but was not genotoxic. DCBP was found to activate CYP450 monooxygenases known to be involved in the metabolism of xenobiotics. Altogether, our results show that aging of Po13 lead to the release of toxic soluble compounds. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-05-07 |
| AnnouncementXML | Submission_2025-05-07_03:06:26.602.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD056061 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Hélène Diemer |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-09-20 07:38:05 | ID requested | |
| ⏵ 1 | 2025-05-07 03:06:27 | announced | |
Publication List
| 10.6019/PXD056061; |
| Aubry L, Vitipon M, Hirschler A, Diemer H, Rabilloud T, Carapito C, Douki T, Accelerated aging modulates the toxicological properties of the diazo tattoo pigment PO13. Sci Rep, 15(1):695(2025) [pubmed] |
| 10.1038/s41598-024-83713-9; |
Keyword List
| submitter keyword: Tattoo, skin toxicity, nanoLC-MS/MS |
Contact List
| Christine Carapito |
|---|
| contact affiliation | Laboratoire de Spectrometrie de Masse BioOrganique (LSMBO), Universite de Strasbourg, CNRS, IPHC UMR 7178, 67087 Strasbourg, France |
| contact email | ccarapito@unistra.fr |
| lab head | |
| Hélène Diemer |
|---|
| contact affiliation | LSMBO |
| contact email | hdiemer@unistra.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD056061 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD056061
- Label: PRIDE project
- Name: Accelerated aging modulates the toxicological properties of the diazo tattoo pigment Po13
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