PXD056031-1

PXD056031 is an original dataset announced via ProteomeXchange.

Title	Proteomic characterization of Opisthorchis viverrini excretory/secretory products
Description	O. viverrini infection is recognised by the WHO as a group 1 biological carcinogen because of its extremely strong link with cholangiocarcinoma (CCA), cancer of the bile ducts. The incidence of CCA associated with liver fluke infection, calculated as an age‐standardized rate, varies by geographical region and other risk factors but exceeds 100 per 100,000 in men and 40 per 100,000 in women in hotspots in northeast Thailand. Any attempts to control liver fluke infection, whether through mass drug administration or ultimately through vaccination requires specific and sensitive diagnostic tools that are readily deployable in the field and easy to use. It is imperative that methods to detect infection are appropriately sensitive and rapid in order to diagnose new cases, assess effectiveness of elimination measures and be applicable to large-scale disease surveillance. Indeed, the WHO recently highlighted the low sensitivity of current diagnostic methods as a barrier to controlling liver fluke infection. Herein, we have leveraged the O. viverrini soluble secreted proteome to help create the first O. viverrini protein microarray.
HostingRepository	PRIDE
AnnounceDate	2024-09-20
AnnouncementXML	Submission_2024-09-20_04:55:18.539.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD056031
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Javier Sotillo
SpeciesList	scientific name: Opisthorchis; NCBI TaxID: 6197;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-19 10:59:44	ID requested
⏵ 1	2024-09-20 04:55:18	announced

10.6019/PXD056031;

submitter keyword: proteomics, excretory/secretory products,Opisthochis viverrini, secretome

Javier Sotillo
contact affiliation	Instituto de Salud Carlos III
contact email	javier.sotillo@isciii.es
lab head
Javier Sotillo
contact affiliation	Instituto de Salud Carlos III
contact email	javier.sotillo@isciii.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD056031

PRIDE project URI

• PRIDE
  1. PXD056031
     1. Label: PRIDE project
     2. Name: Proteomic characterization of Opisthorchis viverrini excretory/secretory products