PXD056004-1

PXD056004 is an original dataset announced via ProteomeXchange.

Title	Exploring the vault interactome in the divergent eukaryote Trypanosoma brucei
Description	Many, but not all Eukaryotes have protein-enclosed compartments called vaults. Vaults are composed of multiple copies of the major vault protein (MVP), symmetrically assembled into a basket like shell. Whilst there is some evidence that these compartments are engaging in mRNA maturation and intriguing structural information of the vault shell is available, the function of vaults remains largely elusive. Here, we set out to explore the vault interactome in the early branching eukaryote Trypanosoma brucei employing a combination of affinity capture and TurboID proximity labelling.
HostingRepository	PRIDE
AnnounceDate	2024-12-12
AnnouncementXML	Submission_2024-12-12_08:07:55.641.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martin Zoltner
SpeciesList	scientific name: Trypanosoma brucei; NCBI TaxID: 5691;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-19 01:03:22	ID requested
⏵ 1	2024-12-12 08:07:56	announced

Dataset with its publication pending

submitter keyword: trypanosoma, affinity isolation,major vault protein, cryomilling, BioID, vault particle

Dr. Martin Zoltner
contact affiliation	Head of Drug Discovery and Evaluation Charles University in Prague, BIOCEV Průmyslová 595 252 50 Vestec Czech Republic phone: +420 325 873 966
contact email	zoltnerm@natur.cuni.cz
lab head
Martin Zoltner
contact affiliation	Division of Biological Chemistry & Drug Discovery School of Life Sciences University of Dundee Dundee DD1 5EH
contact email	m.zoltner@dundee.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD056004
     1. Label: PRIDE project
     2. Name: Exploring the vault interactome in the divergent eukaryote Trypanosoma brucei