PXD055979-1

PXD055979 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteome of mouse PHB68b T-Cells +/- α-CD3/α-CD28 stimulation
Description	Prohibitin 2 (PHB2) is a highly conserved protein with essential roles in cell homeostasis and survival across different cell types. Previous studies have shown that the deletion of PHB2 results in an arrest in proliferation due to impaired mitochondrial function regulated by the dynamin-like GTPase OPA1. The function of PHB2 in immune cells remains unclear, however, some studies suggest that PHB2 plays a role in the cell membranes of B and T cells. In order to elucidate the role of PHB2 in immune cells, we performed an LC-MS analysis in DIA mode of generated PHB2-deficient T cells with and without the α-CD3/α-CD28 stimulation.
HostingRepository	jPOST
AnnounceDate	2025-09-18
AnnouncementXML	Submission_2025-09-17_08:00:04.548.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Assel Nurbekova
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue
Instrument	6520A Quadrupole Time-of-Flight LC/MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-18 06:59:45	ID requested
⏵ 1	2025-09-17 08:00:04	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: T cell, prohibitin 2

submitter keyword: T cell, prohibitin 2

Contact List

Dr Nadine Hövelmeyer (hoevelme@uni-mainz.de)
lab head
Assel Nurbekova
contact affiliation	University Medical Center
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003367/