PXD055964-1

PXD055964 is an original dataset announced via ProteomeXchange.

Title	Declining activity of serum response factor in aging arteries in relation to aortic aneurysm initiation and progression
Description	public RNA-sequencing data were leveraged to define how the transcriptome of healthy human arteries remodels with age, uncovering both known and novel age-dependent processes. We demonstrate for the first time that the SRF regulon is gradually depleted in the aging arterial wall, and that this, when mimicked by genetic SRF depletion in young mice, impairs contractility and elicits aortic remodeling and mucoid extracellular matrix accumulation which are hallmarks of aneurysmal disease. Moreover, aortic reduction of SRF mimics a molecular signature of Ang II treatment, an intervention that causes aortic aneurysm in and by itself.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_03:06:05.360.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joakim Bastrup
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-18 00:33:46	ID requested
⏵ 1	2025-05-07 03:06:06	announced

Rippe C, Bastrup JA, Holmberg J, Kawka K, Ar, é, valo Martinez M, Albinsson S, Jepps TA, Sw, ä, rd K, Declining activity of serum response factor in aging aorta in relation to aneurysm progression. J Biol Chem, 301(4):108400(2025) [pubmed]

10.1016/j.jbc.2025.108400;

submitter keyword: myosin light chain kinase, leiomodin,myocardin, smooth muscle gamma-actin, hypertension, angiotensin

Thomas Jepps
contact affiliation	University of Copenhagen, Department of Biomedical Sciences, Jepps Lab, Copenhagen, Denmark
contact email	tjepps@sund.ku.dk
lab head
Joakim Bastrup
contact affiliation	Department of Biomedical Sciences, University of Copenhagen, Denmark
contact email	joakimbastrup@hotmail.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD055964

PRIDE project URI

• PRIDE
  1. PXD055964
     1. Label: PRIDE project
     2. Name: Declining activity of serum response factor in aging arteries in relation to aortic aneurysm initiation and progression