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PXD055963-1

PXD055963 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComparative Proteomic Analysis of Astrocytoma Tissues from Patients with and without Seizures
DescriptionAstrocytoma is a common type of glioma and a frequent cause of brain tumour-related epilepsy. Although the link between glioma and epilepsy is well established, the precise mechanisms underlying epileptogenesis in astrocytoma remain poorly understood. In this study, we performed proteomic analysis of astrocytoma tissue from patients with and without seizures using mass spectrometry-based techniques. We detected 131 differentially expressed proteins (42 upregulated and 89 downregulated). Proteins upregulated in patients with seizures were mostly related to an increase in energy metabolism. Moreover, glial fibrillary acidic protein, which is involved in maintaining normal axonal structures, was abnormally highly expressed in patients with seizures. Proteins downregulated in patients with seizures included those involved in trans-synaptic signalling and gamma-aminobutyric acid synaptic transmission. Interestingly, comparison of protein expression profiles from our cohort with those from a previous study of patients with epilepsy due to other causes showed that the collapsin response mediator protein family of axonal growth regulators was highly expressed only in patients with seizures due to astrocytomas. Further studies of the proteins identified here are required to determine their potential as biomarkers and therapeutic targets.
HostingRepositoryjPOST
AnnounceDate2024-09-23
AnnouncementXMLSubmission_2024-09-23_06:16:46.628.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKittinun Leetanaporn
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListS-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrumentinstrument
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-09-18 00:24:01ID requested
12024-09-23 06:16:47announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: proteomics, astrocytoma, seizure, pathway analysis
Contact List
Kanitpong Phabphal
lab head
Kittinun Leetanaporn
contact affiliationPrince of Songkla University
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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