PXD055962-1

PXD055962 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of the putamen and the entorhinal cortex of macaques injected with synuclein seeds from Parkinson’s brain
Description	The dynamics of the "prion-like" features of Parkinson’s disease (PD) has never been experimentally studied in primates phylogenetically close to humans. We injected 37 baboons in the striatum with picograms of two distinct α-synuclein proteopathic seeds purified from PD brains, differentiating by their size (large or small). After neuropathological examination of the baboon’s brain, we also performed mass spectrometry-based proteomics of baboons’ putamen and entorhinal cortex to study the temporal and spatial response (local and distant) to α-synuclein seeds injections.
HostingRepository	PRIDE
AnnounceDate	2025-05-09
AnnouncementXML	Submission_2025-05-08_22:23:47.857.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stephane Claverol
SpeciesList	scientific name: Papio; NCBI TaxID: 9554;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-18 00:17:26	ID requested
⏵ 1	2025-05-08 22:23:48	announced

10.1126/SCIADV.ADU6050;

submitter keyword: non-human primates,Parkinson disease, neurodegeneration

S Claverol
contact affiliation	Univ. Bordeaux, Bordeaux Proteome, Bordeaux, France
contact email	stephane.claverol@u-bordeaux.fr
lab head
Stephane Claverol
contact affiliation	Plateforme Proteome
contact email	stephane.claverol@u-bordeaux.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD055962
     1. Label: PRIDE project
     2. Name: Proteomic analysis of the putamen and the entorhinal cortex of macaques injected with synuclein seeds from Parkinson’s brain