PXD055866-1

PXD055866 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Engineering platelets as targeted protein degraders
Description	We covalently tethered the POI ligand to heat shock protein 90 (HSP90) within platelets through ligand-directed covalent labeling method mediated by the N-acyl-N-alkyl sulfonamide (NASA) linker. These proteolytic platelets, termed DePLT, could selectively accumulate at wound-associated disease sites and then potently degrade the POI by repurposing the critical role of molecular chaperones in protein processing.
HostingRepository	PRIDE
AnnounceDate	2025-12-08
AnnouncementXML	Submission_2025-12-07_16:39:11.067.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yu Chen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-14 15:09:34	ID requested
⏵ 1	2025-12-07 16:39:11	announced

Publication List

Chen Y, Pal S, Li W, Liu F, Yuan S, Hu Q, Engineered platelets as targeted protein degraders and application to breast cancer models. Nat Biotechnol, 43(11):1800-1812(2025) [pubmed]
10.1038/s41587-024-02494-8;

Chen Y, Pal S, Li W, Liu F, Yuan S, Hu Q, Engineered platelets as targeted protein degraders and application to breast cancer models. Nat Biotechnol, 43(11):1800-1812(2025) [pubmed]

10.1038/s41587-024-02494-8;

Keyword List

submitter keyword: Mouse
Breast cancer
Platelets
Targeted protein degradation
BRD4

submitter keyword: Mouse

Breast cancer

Platelets

Targeted protein degradation

BRD4

Contact List

Quanyin Hu
contact affiliation	School of Pharmacy, University of Wisconsin-Madison (UW-Madison)
contact email	qhu66@wisc.edu
lab head
Yu Chen
contact affiliation	University of Wisconsin-Madison
contact email	ychen2332@wisc.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD055866
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD055866

PRIDE project URI

Repository Record List

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