PXD055854-1

PXD055854 is an original dataset announced via ProteomeXchange.

Title	Deep learning to decode sites of RNA translation in normal and cancerous tissues
Description	The biological process of RNA translation is fundamental to cellular life and has wide-ranging implications for human disease. Yet, accurately delineating the variation in RNA translation represents a significant challenge. Here, we develop RiboTIE, a transformer model-based approach to map global RNA translation. We find that RiboTIE offers unparalleled precision and sensitivity for ribosome profiling data. Application of RiboTIE to normal brain and medulloblastoma cancer samples enables high-resolution insights into disease regulation of RNA translation.
HostingRepository	PRIDE
AnnounceDate	2024-12-13
AnnouncementXML	Submission_2024-12-13_11:01:08.524.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jim Clauwaert
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Ascend

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-13 11:27:50	ID requested
⏵ 1	2024-12-13 11:01:08	announced

Dataset with its publication pending

submitter keyword: Ribosome profiling, mass spectrometry,Medulloblastoma

John Prensner
contact affiliation	Department of Pediatrics and Biological Chemistry, University of Michigan
contact email	prensner@umich.edu
lab head
Jim Clauwaert
contact affiliation	University of Michigan
contact email	jimclauwaert@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD055854

PRIDE project URI

• PRIDE
  1. PXD055854
     1. Label: PRIDE project
     2. Name: Deep learning to decode sites of RNA translation in normal and cancerous tissues