PXD055816-1

PXD055816 is an original dataset announced via ProteomeXchange.

Title	Deep proteome profiling of dorsal root ganglia after nerve injury deciphers shared signatures in adolescent and adult male and female mice
Description	Our understanding of how sex and age influence pathological pain at the molecular level is still limited. This is of high relevance for pediatric and adolescent patients, as they are known to be particularly vulnerable to long-term consequences of pathological pain. Here, we leveraged deep proteome profiling of mouse dorsal root ganglia (DRG) from the spared nerve injury (SNI)-model of neuropathic pain and investigated adolescent (4-week-old) and adult (12-week-old) male and female mice in parallel. Differential expression and multidimensional analysis enabled us to reveal sex- and age-dependent proteome regulation upon nerve injury. To enhance the translational significance of our findings, we determined shared proteome signatures among tested sex and age groups. By cross-referencing our results with human DRG data evolutionary conserved molecular patterns were identified. These not only bridge the gap between animal models and human biology, but also offer valuable insights for drug discovery efforts benefiting adolescents, women, and men equally. Overall, we provide an innovative resource that allows researchers to gain a more nuanced understanding of nerve injury-induced changes in mouse DRG. Our findings have significant implications for translational research, potentially accelerating discoveries in peripheral nervous system function and pain.
HostingRepository	PRIDE
AnnounceDate	2024-12-20
AnnouncementXML	Submission_2024-12-20_04:20:18.296.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Feng Xian
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-12 06:13:48	ID requested
⏵ 1	2024-12-20 04:20:18	announced

10.1016/J.PHRS.2024.107552;

submitter keyword: pediatric,neuropathic pain, proteomics, chronic pain, MEFISTO, peripheral nervous system, sex similarities, nerve injury, dorsal root ganglia, proteome

Manuela Schmidt
contact affiliation	Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna
contact email	manuela_schmidt@univie.ac.at
lab head
Feng Xian
contact affiliation	Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna
contact email	feng.xian@univie.ac.at
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD055816
     1. Label: PRIDE project
     2. Name: Deep proteome profiling of dorsal root ganglia after nerve injury deciphers shared signatures in adolescent and adult male and female mice