PXD055784 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Synapse-centered novel omics targets in Alzheimer’s disease |
| Description | Synapse dysfunction is an early event of Alzheimer’s disease (AD). It is caused by multiple cellular and pathological factors such as Amyloid beta, p-tau, inflammation, and aging. However, the exact molecular mechanism of synapse dysfunction in AD is largely unknown. Therefore, to understand the molecular basis of synapse dysfunction in AD, we conducted a high throughput multi-omics analysis of the synaptosome fraction in postmortem brain samples from AD patients and cognitively normal individuals. First, microRNA and mRNA HiSeq analysis were performed on the synaptosomes extracted from the postmortem brains of unaffected control (UC) individuals and AD patients. Next, we conducted the mass spectrometry analysis of synaptosomal proteins in the same sample group of HC and AD. The transcriptomic and proteomic profiling of synaptosome showed the significant deregulation of miRNA, mRNA and protein signatures in AD vs HC. Further, we used an integrated transcriptomic and proteomic approach to understand the molecular interactions of deregulated synapse miRNAs, mRNAs, and proteins in the same samples of AD and HC. Multi-omics integration analysis of synapse miRNAs-mRNAs-proteins revealed the involvement of omics targets in several biological processes and molecular functions such as signal transduction, protein binding, GABAergic synapse, and synaptic vesicle cycle, etc. Our study unveiled synapse-centered novel omics candidates that could be potential therapeutic targets to restore synapse dysfunction in AD. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-10-27 |
| AnnouncementXML | Submission_2025-10-26_17:14:52.391.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Enrique Ramos |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-09-11 13:54:09 | ID requested | |
| ⏵ 1 | 2025-10-26 17:14:53 | announced | |
Publication List
| Kumar S, Ramos E, Hidalgo A, Rodarte D, Sharma B, Torres MM, Devara D, Gadad SS, Integrated multi-omics analyses of synaptosomes revealed synapse-associated novel targets in Alzheimer's disease. Mol Psychiatry, 30(11):5121-5136(2025) [pubmed] |
| 10.1038/s41380-025-03095-w; |
Keyword List
| submitter keyword: proteomics, synaptosome,Alzheimer's |
Contact List
| Subodh Kumar |
|---|
| contact affiliation | Texas Tech University Health Sciences Center - El Paso |
| contact email | subodh.kumar@ttuhsc.edu |
| lab head | |
| Enrique Ramos |
|---|
| contact affiliation | University of Texas at El Paso |
| contact email | eiramos6@utep.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD055784 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD055784
- Label: PRIDE project
- Name: Synapse-centered novel omics targets in Alzheimer’s disease
