PXD055628 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Risk SNP rs11067228-mediated high-order chromatin interactions drive prostate cancer neuroendocrine differentiation through splicing factor SRRM4 |
| Description | Neuroendocrine prostate cancer is an aggressive disease characterized by early metastasis, drug resistance and poor prognosis. Genome-wide association studies (GWAS) previously identified numerous single nucleotide polymorphisms (SNPs) associated with prostate cancer. SNP rs11067228 as a significant variant associated with castration-resistant metastasis (CM) in prostate cancer (PCa). However, mechanisms underlying activity of the rs11067228 risk variant remain unclear. Here, we demonstrated that risk SNP rs11067228 is located in an H3K27ac-enriched active enhancer, and that activity of that region affects castration-resistance and neuroendocrine differentiation in PCa cells. We identified the RNA-splicing factor SRRM4 as a functional target gene as shown in both cell line and xenograft model. In addition, overexpression of SRRM4 is sufficient to induce PCa cell drug resistance and neuroendocrine differentiation. Moreover, site-directed mutation of the rs11067228 non-risk G to the risk A allele enabled binding of the transcription factor SOX4, activating candidate target gene expression. Taken together, our findings indicated that the rs11067228-associated enhancer modulates expression of SRRM4 via allele-specific long-range chromatin interactions, thereby governing PCa drug resistance and neuroendocrine differentiation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-09 |
| AnnouncementXML | Submission_2026-02-08_16:08:17.711.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuan Jiang |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-09-06 05:14:49 | ID requested | |
| ⏵ 1 | 2026-02-08 16:08:18 | announced | |
Publication List
| 10.7150/ijbs.124731; |
| Jiang Y, Zhao Z, Li P, Su G, Qian Y, Zhao Y, Wang B, Bai Y, Zhang L, Zhao Z, Shi J, Lu W, The castration-resistant prostate cancer-associated SNP rs11067228 facilitates neuroendocrine differentiation through an enhancer-mediated chromatin interaction with SRRM4. Int J Biol Sci, 22(3):1440-1460(2026) [pubmed] |
Keyword List
| ProteomeXchange project tag: Human Proteome Project |
| submitter keyword: SNP rs11067228 |
| enhancer |
| long-range chromatin interaction |
| neuroendocrine differentiation |
| prostate cancer |
Contact List
| Wange Lu |
|---|
| contact affiliation | Nankai University |
| contact email | wangelv@gmail.com |
| lab head | |
| Yuan Jiang |
|---|
| contact affiliation | Nankai University |
| contact email | 1120210556@mail.nankai.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD055628
- Label: PRIDE project
- Name: Risk SNP rs11067228-mediated high-order chromatin interactions drive prostate cancer neuroendocrine differentiation through splicing factor SRRM4
