PXD055617-1

PXD055617 is an original dataset announced via ProteomeXchange.

Title	Interaction with AK2 establishes AIFM1 as organizing platform in mitochondria
Description	Interactome of overexpressed, HA-tagged AIFM1 in HEK293T AIFM1 KO background vs control (3797, 3593), Interactome of overexpressed, HA-tagged AIFM1 variants in HEK293T AIFM1 KO background vs control (3859), Comparison of whole cell extract after gelfiltration of HEK293T AIFM1 KO cell line vs WT
HostingRepository	PRIDE
AnnounceDate	2025-08-04
AnnouncementXML	Submission_2025-08-03_16:13:19.338.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Prerana Wagle
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Orbitrap Exploris 480; Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-06 00:58:32	ID requested
⏵ 1	2025-08-03 16:13:20	announced

Rothemann RA, Pavlenko E, Mondal M, Gerlich S, Grobushkin P, Mostert S, Racho J, Weiss K, Stobbe D, Stillger K, Lapacz K, Salscheider SL, Petrungaro C, Ehninger D, Nguyen THD, Dengjel J, Neundorf I, Bano D, Poepsel S, Riemer J, Interaction with AK2A links AIFM1 to cellular energy metabolism. Mol Cell, 85(13):2550-2566.e6(2025) [pubmed]

10.1016/j.molcel.2025.05.036;

submitter keyword: AIFM1, AK2, mitochondria

Jan Riemer
contact affiliation	Redox Metabolism, Institute for Biochemistry, University of Cologne
contact email	jan.riemer@uni-koeln.de
lab head
Prerana Wagle
contact affiliation	CECAD Research Center
contact email	proteomics-facility@uni-koeln.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD055617

PRIDE project URI

• PRIDE
  1. PXD055617
     1. Label: PRIDE project
     2. Name: Interaction with AK2 establishes AIFM1 as organizing platform in mitochondria