PXD055527-1

PXD055527 is an original dataset announced via ProteomeXchange.

Title	Spatiotemporal Proteomic and Transcriptomic Landscape of DAT+ Dopaminergic Neurons Development and Function
Description	Dopaminergic (DA) neurons marked by the dopamine transporter (DAT) have multiple physiological functions and are involved in the regulation of mental and neurological diseases, prompting in-depth studies into their development and functions. This research explores the spatiotemporal proteomic and transcriptomic changes in DAT+ DA neurons within key brain regions involved in DA signaling—the nucleus accumbens (NAc), substantia nigra (SNc), and ventral tegmental area (VTA). Utilizing cutting-edge multi-omics techniques, such as ultrasensitive trace sample proteomics and SMART-seq2 for transcriptomics, we examine the DA neuronal system at critical postnatal milestones: postnatal day 7 (P7), postnatal day 30 (P30), and postnatal day 60 (P60). The study reveals unique molecular profiles within DA neuron populations, showcasing their varied functional roles and developmental progression.
HostingRepository	iProX
AnnounceDate	2024-09-03
AnnouncementXML	Submission_2024-09-03_20:03:13.908.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Heyu Zhao
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-03 20:01:20	ID requested
⏵ 1	2024-09-03 20:03:14	announced

Dataset with its publication pending

submitter keyword: Brain region, DAT+ Dopaminergic Neurons, Proteomics, Transcriptomics, Aldh1a1, Neuron development

Huali Shen
contact affiliation	Fudan University
contact email	shenhuali@fudan.edu.cn
lab head
Heyu Zhao
contact affiliation	Fudan University
contact email	zhaohy16@fudan.edu.cn
dataset submitter

iProX dataset URI