<<< Full experiment listing

PXD055495-1

PXD055495 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLenalidomide-induced pure red cell aplasia analysis
DescriptionThe RVd therapy, combining lenalidomide, bortezomib, and dexamethasone, is a mainstay treatment for multiple myeloma. A multiple myeloma patient developed pure red cell aplasia (PRCA) following RVd treatment, despite the absence of common PRCA triggers. In vitro analyses revealed lenalidomide as a pivotal disruptor of erythropoiesis. Single-cell transcriptome analysis unveiled hyperactive CD8+ T cells and impaired erythropoiesis in the patient's bone marrow. Unexpectedly, the patient's erythroid cells displayed abnormally high expression of genes in the antigen presentation pathway, particularly those for major histocompatibility class I (MHC-I) molecules. Functional assays demonstrated that lenalidomide treatment further augmented MHC-I expression in the patient's erythroid cells. Blocking MHC-I or depleting T cells alleviate the defective erythropoiesis of PRCA, suggesting that the interaction between erythroid cells with elevated MHC-I and T cells in the bone marrow might contribute to PRCA. Taken together, our study revealed a novel mechanism underlying lenalidomide-induced PRCA in treating cancer patients.
HostingRepositoryiProX
AnnounceDate2024-09-03
AnnouncementXMLSubmission_2024-09-02_20:31:07.438.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterQi Hu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Astral
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-09-02 20:30:57ID requested
12024-09-02 20:31:07announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: MHC-I, PRCA
Contact List
Hsiang-Ying Lee
contact affiliationPeking University
contact emailslee@pku.edu.cn
lab head
Qi Hu
contact affiliationPeking University
contact emailmolinta1124@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI