PXD055494-1

PXD055494 is an original dataset announced via ProteomeXchange.

Title	Effect of WS974536 on astrocyte proteomics
Description	Astrocyte-derived L-serine was found to regulate interstitial D-serine levels and seizure activity in a process controlled by phosphoserine phosphatase (PSPH). We identified a potent PSPH inhibitor, WS974536,nd found that its systemic administration dramatically reduced the frequency of spontaneous epileptic discharges in mouse and cynomolgus monkey models of TLE. In the project. We studied the effect of WS974536 on astrocytes by proteomics.
HostingRepository	iProX
AnnounceDate	2024-09-03
AnnouncementXML	Submission_2024-09-02_20:27:34.817.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yanbing Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-02 20:26:45	ID requested
⏵ 1	2024-09-02 20:27:35	announced

Dataset with its publication pending

submitter keyword: Temporal lobe epilepsy, WS974536, PSPH, serine, proteomics

Xu Qi
contact affiliation	Chinese Academy of Medical Sciences and Peking Union Medical College
contact email	xuqi@pumc.edu.cn
lab head
Yanbing Wang
contact affiliation	Chinese Academy of Medical Sciences and Peking Union Medical College
contact email	w18634306858@163.com
dataset submitter

iProX dataset URI