PXD055480-1

PXD055480 is an original dataset announced via ProteomeXchange.

Title	Identification of factors involved in the adaptation to superoxide stress in pathogenic Leptospira
Description	Pathogenic leptospires are responsible for the zoonotic disease leptospirosis. The clinical manifestations of this infection range from a febrile state to a severe life-threatening form characterized by multiple organ hemorrhages. More than one million cases of leptospirosis are currently reported annually in the word, with 10% of mortality. Leptospira penetrate hosts and rapidly disseminate to target organs (including kidney, liver, lungs) throughout the bloodstream. During infection, Leptospira are confronted with dramatic adverse environmental changes such as deadly reactive oxygen species (ROS). We used proteomic analyses to identify the factors that constitute the adaptive response to superoxide stress in the pathogenic model Leptospira interrogans.
HostingRepository	PRIDE
AnnounceDate	2025-07-10
AnnouncementXML	Submission_2025-07-10_11:41:27.511.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alejandro Leyva
SpeciesList	scientific name: Leptospira interrogans serovar Manilae; NCBI TaxID: 214675;
ModificationList	L-cysteine sulfinic acid; monohydroxylated residue; L-cysteic acid (L-cysteine sulfonic acid); iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-02 13:11:19	ID requested
⏵ 1	2025-07-10 11:41:27	announced

Dataset with its publication pending

submitter keyword: Leptospira,Superoxide, oxidative stress, spirochetes, LC-MS/MS

Rosario Duran
contact affiliation	Analytical Biochemistry and Proteomics Unit, Institut Pasteur de Montevideo & Instituto de Investigaciones Biológicas Clemente Estable
contact email	duran@pasteur.edu.uy
lab head
Alejandro Leyva
contact affiliation	Institut Pasteur de Montevideo
contact email	alejandrolp@pasteur.edu.uy
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD055480

PRIDE project URI

• PRIDE
  1. PXD055480
     1. Label: PRIDE project
     2. Name: Identification of factors involved in the adaptation to superoxide stress in pathogenic Leptospira