PXD055466-1

PXD055466 is an original dataset announced via ProteomeXchange.

Title	Mass spectrometry identification of Akkermansia muciniphila -Caco2 cells interaction proteins
Description	Akkermansia muciniphila is recognized as a promising probiotic that improves the symptoms of a variety of diseases. However, the role and mechanism of A. muciniphila in regulating intestinal homeostasis remain to be explored. Here, we discovered that A. muciniphila was dramatically increased during colitis recovery, and its colonization greatly increased goblet cells to protect the intestinal barrier in mice. Amuc_0904, a previously uncharacterized A. muciniphila outer membrane protein, was identified to induce goblet cell differentiation.We want to find the receptors that 904 interacts with cells to explore the detailed mechanism.
HostingRepository	PRIDE
AnnounceDate	2024-09-02
AnnouncementXML	Submission_2024-09-02_04:42:35.560.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	kaichen zhou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-02 02:35:39	ID requested
⏵ 1	2024-09-02 04:42:35	announced
2	2024-10-22 06:57:38	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Akkermansia muciniphila，Mass spectrometry

Quan Wang
contact affiliation	Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
contact email	yangliu0302@tmu.edu.cn
lab head
kaichen zhou
contact affiliation	Beijing Institute of Genomics, Chinese Academy of Sciences
contact email	zhoukaichen@big.ac.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD055466

PRIDE project URI

• PRIDE
  1. PXD055466
     1. Label: PRIDE project
     2. Name: Mass spectrometry identification of Akkermansia muciniphila -Caco2 cells interaction proteins