PXD055453-1

PXD055453 is an original dataset announced via ProteomeXchange.

Title	Clinical response characteristics of salivary proteins in the management strategy of diabetes-associated periodontitis
Description	Diabetes and periodontitis, as widespread chronic diseases, often exacerbate each other's conditions. Non-surgical periodontal treatments can improve the oral and systemic health in these patients, with salivary proteins offering potential insights into disease mechanisms and treatment effectiveness. However, there is a lack of comprehensive data on salivary proteomics in this context. By assigning patients with diabetes-associated periodontitis to a test group (supragingival scaling, subgingival scraping and root planing) or a control group (supragingival scaling only), analyzing non-stimulated whole saliva samples using liquid chromatography-tandem mass spectrometry, and establishing the in vivo and in vitro models, we found significant differential expression of salivary proteins related to Apelin signaling pathway, hematopoietic cell profiling, stress response and immune regulation, identifying four candidate proteins: superoxide dismutase 1 (SOD1), profilin 1 (PFN1), S100 calcium-binding protein A11 (S100A11) and kallikrein-related peptidase 6 (KLK6). All four proteins were significantly elevated, with a combined area under the curve of 0.933, while SOD1 alone reached 0.915. Additionally, we observed high glucose and inflammatory conditions reduced SOD1 expression. In conclusion, SOD1 emerges as a promising regulatory target for managing diabetes and periodontitis by modulating the oral oxidative stress microenvironment.
HostingRepository	iProX
AnnounceDate	2024-09-01
AnnouncementXML	Submission_2024-12-08_19:29:56.127.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shuyuan Jia
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF; Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-01 22:45:21	ID requested
⏵ 1	2024-12-08 19:29:56	announced

Dataset with its publication pending

submitter keyword: salivary proteomics, biomarkers, chronic disease management, diabetes, periodontitis

Chao Yuan
contact affiliation	Department of Preventive Dentistry, Peking University School and Hospital of Stomatology
contact email	chaoyuan@bjmu.edu.cn
lab head
Shuyuan Jia
contact affiliation	Department of Preventive Dentistry, Peking University School and Hospital of Stomatology
contact email	jiashuyuancindy@163.com
dataset submitter

iProX dataset URI