PXD055452-2

PXD055452 is an original dataset announced via ProteomeXchange.

Title	4D-DIA-based quantitative proteomic analysis reveals the involvement of TRPV2 protein in duck Tembusu virus replication
Description	Using a quantitative proteomics approach based on 4D-DIA combined with LC-MS/MS analysis, we identified TRPV2 as a potential host resistance factor that was significantly upregulated in DF-1 cells 48 hours post-DTMUV infection. Further experiments involving siRNA-mediated knockdown of TRPV2 expression in DF-1 cells revealed that suppression of TRPV2 expression inhibited DTMUV replication within the cells. Therefore, TRPV2 emerges as a promising candidate for poultry breeding programs aimed at enhancing resistance against DTMUV infection, serving as a potential target for the development of DTMUV-resistant animals in avian breeding.
HostingRepository	iProX
AnnounceDate	2024-09-01
AnnouncementXML	Submission_2025-11-26_19:10:15.605.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Huihuang Li
SpeciesList	scientific name: Gallus gallus; NCBI TaxID: 9031;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-01 22:41:28	ID requested
1	2024-09-01 22:43:18	announced
⏵ 2	2025-11-26 19:10:16	announced	2025-11-27: Add info

Chen J, Yang F, Lai L, Li H, Pan C, Bao X, Lin W, Lin R, 4D-DIA-Based Quantitative Proteomic Analysis Reveals the Involvement of TRPV2 Protein in Duck Tembusu Virus Replication. Viruses, 16(12):(2024) [pubmed]

submitter keyword: Duck Tembusu virus, Quantitative proteomics, DF-1 cells, TRPV2

Ruiyi Lin
contact affiliation	Fujian Agriculture and Forest University College of Animal Science
contact email	linruiyi@fafu.edu.cn
lab head
Huihuang Li
contact affiliation	Fujian Agriculture and Forest University College of Animal Science
contact email	lihuihuang@fafu.edu.cn
dataset submitter

iProX dataset URI