PXD055444-1

PXD055444 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of the effects of Shenzhu Tiaopi granules on model rats with type 2 diabetes mellitus
Description	In total, 5856 proteins were identified via proteomics analysis, 97 of which were significantly differentially expressed in the liver and affected fatty acid metabolism, unsaturated fatty acid biosynthesis, the peroxisome proliferator-activated receptor (PPAR) signalling pathway, pyruvate metabolism, and terpenoid backbone biosynthesis. Screening identified 10 target proteins, including perilipin‐2 (Plin2), Pdk4, farnesyl diphosphate synthase (Fdps) and Fdft1. Among these, the key proteins were Plin2 and Fdps, which were found to be associated with the PPAR signalling pathway and terpenoid backbone biosynthesis via the relationship networks
HostingRepository	iProX
AnnounceDate	2024-08-30
AnnouncementXML	Submission_2024-09-01_20:14:25.335.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jindong Zhao
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-01 20:14:13	ID requested
⏵ 1	2024-09-01 20:14:25	announced

Dataset with its publication pending

submitter keyword: type 2 diabetes mellitus, improving hyperglycaemia, proteomics, Fdps, Plin2, Shenzhu Tiaopi granule

Jindong Zhao
contact affiliation	the First Affiliated Hospital of Anhui University of Chinese Medicine
contact email	fangzhaohui1111@163.com
lab head
Jindong Zhao
contact affiliation	the First Affiliated Hospital of Anhui University of Chinese Medicine
contact email	zhaojindong1111@outlook.com
dataset submitter

iProX dataset URI