PXD055404-1

PXD055404 is an original dataset announced via ProteomeXchange.

Title	The immune microenvironment in prurigo nodularis leads to dysfunction of epidermal cells and their extracellular vesicles
Description	In this study, we constructed the proteomics profiles of PN EpCs and PN EpC-derived exosomes using the quantitative proteomics techniques. Our findings revealed that EpCs in PN patients exhibit abnormal morphology and biological functions, which are influenced by the high metabolic levels and activation of inflammasome pathways in the immune microenvironment. Meanwhile, the exosomes and ECMs secreted by the dysfunctional epidermal cells could further affect the immune microenvironment. This study aims to identify potential targets for disease treatment by analyzing the relationship between PN epidermal cells, extracellular vesicles, and the immune microenvironment. These results can provide guidance in the discovery of improved clinical treatments for PN.
HostingRepository	iProX
AnnounceDate	2024-08-31
AnnouncementXML	Submission_2025-12-14_22:58:45.215.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenjuan Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-30 20:49:45	ID requested
⏵ 1	2025-12-14 22:58:45	announced

Dataset with its publication pending

submitter keyword: Prurigo nodularis, epidermal cells, epidermal cell-derived exosomes, microenvironment, proteomics

Ling Leng
contact affiliation	Peking Union Medical College Hospital
contact email	lengling@pumch.cn
lab head
Wenjuan Wang
contact affiliation	First Medical Center of Chinese PLA General Hospital
contact email	phenix123@126.com
dataset submitter

iProX dataset URI