PXD055378 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Characterizing heterologous protein burden in Komagataella phaffii |
| Description | In this study, we explore the molecular response of various K. phaffii strains that produce either the human insulin precursor or Mambalgin-1, examining changes in transcription and changes in intra- and extracellular protein levels. Our findings provide valuable insights into the molecular mechanisms that regulate the behaviour of K. phaffii production strains under the stress of producing different heterologous proteins. We believe that these results will serve as a foundation for identifying new genetic targets to improve strain robustness and productivity |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-03-12 |
| AnnouncementXML | Submission_2025-03-12_13:08:06.355.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD055378 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Louise Kastberg |
| SpeciesList | scientific name: Komagataella pastoris (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris); NCBI TaxID: 644223; |
| ModificationList | acetylated residue; monohydroxylated residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-08-30 03:54:51 | ID requested | |
| ⏵ 1 | 2025-03-12 13:08:07 | announced | |
Publication List
| 10.6019/PXD055378; |
| Kastberg LB, Jacobsen IH, Ö, zdemir E, Workman CT, Jensen MK, F, ö, rster J, Characterizing heterologous protein burden in Komagataella phaffii. FEMS Yeast Res, 25():(2025) [pubmed] |
| 10.1093/femsyr/foaf007; |
Keyword List
| submitter keyword: Komagataella phaffii |
| heterologous protein production |
| burden |
| proteomics |
| continuous cultivation |
Contact List
| Jochen Förster |
|---|
| contact affiliation | Novo Nordisk Foundation Center for Biosustainability |
| contact email | jfor@biosustain.dtu.dk |
| lab head | |
| Louise Kastberg |
|---|
| contact affiliation | Technical University of Denmark, Department of Biotechnology and Biomedicine |
| contact email | llabka@dtu.dk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD055378 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD055378
- Label: PRIDE project
- Name: Characterizing heterologous protein burden in Komagataella phaffii
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