PXD055317-1
PXD055317 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Estrogen inhibits the progression of liver cancer by modulating PRDX-induced ferroptosis |
Description | Liver cancer exhibits significant gender disparities, with men having a 2-5 times higher risk of developing liver cancer compared to women. Numerous studies have demonstrated the influence of estrogen on liver cancer development, although the precise underlying mechanism remains unclear. Peroxiredoxins (PRDXs) represent a recently identified peroxidase family that modulates various signaling pathways associated with reactive oxygen species. This research aims to explore the impact of estrogen on the expression of PRDX1, PRDX5, and PRDX6 in hepatocellular carcinoma cells, thereby modulating liver cancer progression. Treatment with estrogen and the silencing of PRDX1, PRDX5, and PRDX6 impairs the proliferative capacity of hepatocarcinoma cells. The levels of PRDX1, PRDX5, and PRDX6 were found to be elevated in hepatocellular carcinoma compared to normal tissues, with estrogen demonstrating the ability to decrease their expression in hepatocellular carcinoma cells. Furthermore, estrogen influences the expression of PRDXs (PRDX5 and PRDX6) by regulating RASA1. Additionally, estrogen stimulation impacts ferroptosis in hepatocellular carcinoma cells, suggesting that PRDXs and ferroptosis-related genes are estrogen-responsive genes that promote liver cancer progression. Elevated LPCAT3 levels and downregulation of PRDX1, PRDX5, and PRDX6 expression may potentially manage the advancement of HCC. |
HostingRepository | iProX |
AnnounceDate | 2024-08-26 |
AnnouncementXML | Submission_2024-08-28_20:32:36.128.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Chunhua Liu |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-08-28 20:32:26 | ID requested | |
⏵ 1 | 2024-08-28 20:32:36 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: PRDX |
Contact List
Chunhua Liu | |
---|---|
contact affiliation | Shandong First Medical University |
contact email | mimigirl669@163.com |
lab head | |
Chunhua Liu | |
contact affiliation | Shandong First Medical University |
contact email | mimigirl669@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |