PXD055308-1

PXD055308 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomics analysis of endoplasmic reticulum(ER) enrichment
Description	This study explores how cellular stress, particularly ER stress caused by ER-to-Golgi transport blockade, triggers unconventional protein secretion (UPS). The research identifies an ER tubulovesicular structure (ER-TB), shaped by the proteins ATL3 and RTN3L, as key to stress-induced UPS of transmembrane proteins like CFTR and SARS-CoV-2 spike protein. Knockdown of ATL3 and RTN3 disrupts ER-TB formation and UPS, while their combined presence promotes it. The findings suggest that ER-TB plays a crucial role in mitigating ER stress and may be involved in various physiological and pathological processes.
HostingRepository	MassIVE
AnnounceDate	2024-12-15
AnnouncementXML	Submission_2024-12-15_17:35:08.344.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yeji Yang
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-28 18:13:31	ID requested
⏵ 1	2024-12-15 17:35:08	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: endoplasmic reticulum, proteomics, unconventional protein secretion, LC-MS/MS

submitter keyword: endoplasmic reticulum, proteomics, unconventional protein secretion, LC-MS/MS

Contact List

Jin Young Kim
contact affiliation	Korea Basic Science Institute
contact email	jinyoung@kbsi.re.kr
lab head
Yeji Yang
contact affiliation	Korea Basic Science Institute
contact email	yangyj@kbsi.re.kr
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095717/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095717/