PXD055304-1
PXD055304 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Altering translation allows E. coli to overcome chemically stabilized G-quadruplexes |
| Description | Proteomic analysis reveals translation-related proteins are significantly altered in response to stabilized G4s. Identification of the importance of translation factors in overcoming G4s led to the question of how E. coli cells generally respond to chemicals that stabilize such structures. As a first step in addressing this question, a proteomic analysis was carried out to measure the quantitative effects of NMM on the levels of individual proteins in E. coli. Protein levels from early log-phase cultures of delta-tolC and delta-tolC tufA::kan strains grown in the presence or absence of NMM were measured to assess how reduced EF- Tu levels and NMM impacted expression. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-03-18 |
| AnnouncementXML | Submission_2025-03-18_09:34:28.798.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Dain Brademan |
| SpeciesList | scientific name: Escherichia coli; common name: E. coli; NCBI TaxID: 562; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Ascend |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-08-28 16:35:12 | ID requested | |
| ⏵ 1 | 2025-03-18 09:34:29 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Data-dependent acquisition (DDA), Bottom-up proteomics, E.coli, G-quadruplex, Orbitrap Ascend |
Contact List
| Joshua J. Coon | |
|---|---|
| contact affiliation | University of Wisconsin-Madison |
| contact email | jcoon@chem.wisc.edu |
| lab head | |
| Dain Brademan | |
| contact affiliation | Coon Laboratory |
| contact email | brademan@wisc.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095714/ |
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