PXD055206 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Neurodevelopmental Impact of Prenatal Stress: A Proteomic Analysis of Myelination Disruptions in the Avian Embryo |
| Description | Prenatal stress induced by maternal activation of the hypothalamic-pituitary-adrenal (HPA) axis and subsequent release of glucocorticoids can profoundly affect fetal brain development. This study investigates the molecular mechanisms underlying prenatal stress in Gallus gallus domesticus by analyzing the brain proteome of embryos exposed to corticosterone. Using one of the most comprehensive proteomic analyses of the developing chicken brain to date, in which over 6,500 proteins were quantified, we identified significant myelination deficits as a key pathological feature. These results are consistent with previous research in mammalian models, highlighting the utility of Gallus gallus as a non-mammalian model for studying the effects of prenatal stress on neurodevelopment. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-10-27 |
| AnnouncementXML | Submission_2025-10-26_17:23:25.706.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Britta Eggers |
| SpeciesList | scientific name: Gallus gallus (Chicken); NCBI TaxID: NEWT:9031; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-08-26 07:56:44 | ID requested | |
| ⏵ 1 | 2025-10-26 17:23:26 | announced | |
Publication List
| 10.1002/dneu.23003; |
| Gaertner B, Morosan-Puopolo G, Brand-Saberi B, Sch, ü, cke C, Saberi D, Kl, ö, ster K, Faissner S, Marcus K, Gellisch M, Eggers B, Neurodevelopmental Impact of Prenatal Stress: A Proteomic Analysis of Myelination Disruptions in the Avian Embryo. Dev Neurobiol, 85(4):e23003(2025) [pubmed] |
Keyword List
| submitter keyword: gallus gallus domesticus, proteomics, myelin,prenatal stress, corticosterone |
Contact List
| Katrin Marcus |
|---|
| contact affiliation | Medizinisches Proteom-Center, Medical Faculty, Ruhr-University Bochum, 44801 Bochum, Germany; 44801 Bochum, Germany |
| contact email | Katrin.marcus@rub.de |
| lab head | |
| Britta Eggers |
|---|
| contact affiliation | Ruhr University Bochum |
| contact email | britta.eggers@rub.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD055206
- Label: PRIDE project
- Name: Neurodevelopmental Impact of Prenatal Stress: A Proteomic Analysis of Myelination Disruptions in the Avian Embryo
