PXD055164-1

PXD055164 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomics guides low dose drug combination of cisplatin and silmitasertib against concurrent chemoradiation resistant cervical cancer
Description	Cervical cancer is one of the leading causes of cancer related deaths among females. Due to proper screening programmes, most of the cervical cancer cases are presented in the locally advanced stage of the disease. Concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced cervical cancer. However, resistance to CCRT limit the success of the treatment regimen. In this study, we investigated the altered phosphoproteome of CCRT resistant and sensitive cohort using Mass spectrometry-based proteomics. We carried out phosphoproteomic analysis of treatment naïve cervical cancer patients whose response to CCRT is recorded. The Phosphoproteomic analysis revealed kinases and the pathways associated with CCRT resistance in cervical cancer patients.
HostingRepository	PRIDE
AnnounceDate	2024-12-12
AnnouncementXML	Submission_2024-12-11_21:27:49.223.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Irene A George
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-24 04:52:39	ID requested
⏵ 1	2024-12-11 21:27:49	announced

10.1039/D4MO00147H;

submitter keyword: Human, LC-MSMS, Tissue, Cervical Cancer

Prashant Kumar
contact affiliation	Institute of Bioinformatics, Bangalore
contact email	prashant@ibioinformatics.org
lab head
Irene A George
contact affiliation	Institute of Bioinformatics
contact email	irene@ibioinformatics.org
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD055164
     1. Label: PRIDE project
     2. Name: Phosphoproteomics guides low dose drug combination of cisplatin and silmitasertib against concurrent chemoradiation resistant cervical cancer