PXD055138-1

PXD055138 is an original dataset announced via ProteomeXchange.

Title	Plasma-based proteomics analysis of molecular pathways in canine diabetes mellitus after astaxanthin supplementation
Description	The hyperglycemic state in diabetes mellitus (DM) induces oxidative stress and inflammation, thus contributing to diabetic tissue damage and associated complications. Astaxanthin, a potent antioxidant carotenoid, has been investigated for its potential in preventing and managing diabetes across various species, but its effect on client-owned dogs is not well-studied. This study explored the impact of astaxanthin supplementation on canine DM using a proteomic approach. A total of 18 client-owned dogs were enrolled: 6 dogs with DM and 12 clinically healthy dogs. The diabetic dogs received their standard treatment regimen alongside daily oral supplementation of 12 mg of astaxanthin (1.5–2.4 mg/kg) for 90 days. Plasma samples were collected at the beginning and end of the study period for proteomic analysis. After astaxanthin supplementation, there were significant alterations in protein expression associated with the complement system, coagulation cascade, JAK-STAT signaling, and protein kinase C signaling, which all contribute to inflammation and oxidative stress. Astaxanthin demonstrated a protective effect against diabetes-associated complications, including insulin resistance, vascular dysfunction, nephropathy, and cardiac complications. These findings highlight the potential of astaxanthin as a complementary therapeutic agent for controlling DM in canines.
HostingRepository	PRIDE
AnnounceDate	2025-03-17
AnnouncementXML	Submission_2025-03-16_18:58:25.109.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sataporn Phochantachinda
SpeciesList	scientific name: Canis familiaris (Dog) (Canis lupus familiaris); NCBI TaxID: 9615;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	compact

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-23 08:30:21	ID requested
⏵ 1	2025-03-16 18:58:25	announced

10.1371/JOURNAL.PONE.0321509;

submitter keyword: Astaxanthin, Plasma proteomic, Inflammation, Canine diabetic mellitus, Oxidative stress

Piyada Na nakorn
contact affiliation	Center for Research Innovation and Biomedical informatics, Faculty of Medical Technology, Mahidol university
contact email	piyada.nnk@mahidol.edu
lab head
Sataporn Phochantachinda
contact affiliation	Faculty of Veterinary Science, Mahidol University
contact email	sataporn.pho@mahidol.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD055138
     1. Label: PRIDE project
     2. Name: Plasma-based proteomics analysis of molecular pathways in canine diabetes mellitus after astaxanthin supplementation