PXD055119-1

PXD055119 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Quantitative proteomics analysis of acute myeloid leukemia cells after NAT10 knockdown
Description	RNA modification represents an important post-transcriptional regulatory mechanism in acute myeloid leukemia (AML). Given that the critical function of ac4C in control RNA translation, we sought to investigate the global impact of ac4C on protein expression. To this end, we conducted tandem mass tag (TMT) labeling and quantitative proteomics in MOLM13 AML cells with or without the ac4c writer NAT10 silencing.
HostingRepository	PRIDE
AnnounceDate	2024-08-26
AnnouncementXML	Submission_2024-08-26_05:47:04.744.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Huilin Huang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-23 02:54:22	ID requested
⏵ 1	2024-08-26 05:47:05	announced
2	2024-10-22 06:56:31	announced	2024-10-22: Updated project metadata.

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: RNA acetylation (ac4C)
acute myeloid leukemia
leukemic stem cells (LSCs)
metabolic reprogramming
serine synthesis pathway
epigenetic inhibitor

submitter keyword: RNA acetylation (ac4C)

acute myeloid leukemia

leukemic stem cells (LSCs)

metabolic reprogramming

serine synthesis pathway

epigenetic inhibitor

Contact List

Huilin Huang
contact affiliation	State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
contact email	huanghl1@sysucc.org.cn
lab head
Huilin Huang
contact affiliation	Sun Yat-sen University Cancer Center
contact email	huanghl1@sysucc.org.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD055119
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD055119

PRIDE project URI

Repository Record List

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