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PXD055094-1

PXD055094 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleChIRP-MS dataset generated from Prohibitin 2 orchestrating transcription of long noncoding RNA and coding gene to accelerate tumorigenesis
DescriptionThe spatial co-presence of aberrant long non-coding RNAs (lncRNAs) and abnormal coding genes contributes to malignancy development in various tumors. However, precise coordinated mechanisms underlying this phenomenon in tumorigenesis remains incompletely understood. Here, we show that Prohibitin 2 (PHB2) orchestrates the transcription of an oncogenic CASC15-New-Isoform 2 (CANT2) lncRNA and the coding tumor-suppressor gene CCBE1, thereby accelerating melanoma tumorigenesis. In melanoma cells, to further capture the binding proteins of CANT2, ChIRP-MS was performed.
HostingRepositoryPRIDE
AnnounceDate2024-09-05
AnnouncementXMLSubmission_2024-09-04_19:14:29.365.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHe Zhang
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-08-22 19:38:28ID requested
12024-09-04 19:14:29announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Human, melanoma cell, ChIRP-MS
Contact List
He Zhang
contact affiliationTongji University
contact emailzhanghelab@outlook.com
lab head
He Zhang
contact affiliationTongji University
contact emailzhanghelab@outlook.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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