PXD055029-1

PXD055029 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	An intrinsically disordered region of histone demethylase KDM5A regulates catalysis through interactions with the nucleosomal acidic patch and DNA
Description	KDM5A lysine demethylase conformation was probed by BS3 crosslinking in the presence and absence of DNA. Crosslinked proteins were reduced, alkylated with iodoacetamide, trypsin digest, and labeled with TMT6plex reagent prior to mixing and acquisition on an Orbitrap Exploris equiped with a FAIMS source. Three biological replicates are included split over multipe technical replicates and/or SEC fractions. The SampleKey.txt file explains the labeling scheme.
HostingRepository	MassIVE
AnnounceDate	2025-06-26
AnnouncementXML	Submission_2025-06-27_12:40:44.121.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mike Trnka
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Xlink:DSS[156]; TMT6plex
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-21 14:03:20	ID requested
⏵ 1	2025-06-27 12:40:44	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: KDM5A, lysine demethylase, BS3 crosslinking, quantitative crosslinking, DatasetType:Proteomics

submitter keyword: KDM5A, lysine demethylase, BS3 crosslinking, quantitative crosslinking, DatasetType:Proteomics

Contact List

Danica Galonic Fujimori
contact affiliation	University of California San Francisco
contact email	Danica.Fujimori@ucsf.edu
lab head
Mike Trnka
contact affiliation	UCSF
contact email	mtrnka@cgl.ucsf.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097094/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097094/