PXD055025-1

PXD055025 is an original dataset announced via ProteomeXchange.

Title	Proteomic Analysis Reveals Differential Protein Expression in Early-Onset Preeclampsia Patients
Description	Preeclampsia, a significant cause of maternal and perinatal morbidity and mortality, remains poorly understood in terms of its pathogenesis. This study aims to uncover novel and effective biomarkers for preeclampsia by conducting a comparative analysis of differential proteins in placentas from early-onset preeclampsia (EOPE) and normal pregnancies. Utilizing tandem mass tag (TMT)-based quantitative proteomics, we identified differentially expressed proteins in placental tissues from 15 EOPE patients and 15 normal pregnant women. These proteins were subsequently validated using parallel reaction monitoring (PRM). Our analysis revealed a total of 59 differentially expressed proteins, with 25 up-regulated and 34 down-regulated in EOPE placental tissues compared to those from normal pregnancies. Validation through PRM confirmed the differential expression of 6 proteins. Our findings suggest these 6 proteins could play crucial roles in the pathogenesis of EOPE, highlighting the potential involvement of the Estrogen signaling pathway and Dilated cardiomyopathy (DCM) pathway in the development of preeclampsia.
HostingRepository	iProX
AnnounceDate	2024-08-20
AnnouncementXML	Submission_2024-08-20_20:04:26.423.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jing Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-20 19:20:29	ID requested
⏵ 1	2024-08-20 20:04:26	announced

Dataset with its publication pending

submitter keyword: preeclampsia, early-onset preeclampsia (EOPE), biomarkers, proteomics

Jing Li
contact affiliation	The Affiliated Hospital of Qingdao University
contact email	lijing@qdu.edu.cn
lab head
Jing Li
contact affiliation	The Affiliated Hospital of Qingdao University
contact email	lijing@qdu.edu.cn
dataset submitter

iProX dataset URI