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PXD055014-1

PXD055014 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Sortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male mice
Description	Beige fat activation involves a fuel switch to fatty acid oxidation following chronic cold adaptation. Mitochondrial acyl-CoA synthetase long-chain family member 1 (ACSL1) localizes in the mitochondria and plays a key role in fatty acid oxidation; however, the regulatory mechanism of the subcellular localization remains poorly understood. Here, we identify an endosomal trafficking component sortilin (encoded by Sort1) in adipose tissues that shows dynamic expression during beige fat activation and facilitates the translocation of ACSL1 from the mitochondria to the endolysosomal pathway for degradation. Depletion of sortilin in adipocytes results in an increase of mitochondrial ACSL1 and the activation of AMPK/PGC1α signaling, thereby activating beige fat and preventing high-fat diet (HFD)-induced obesity and insulin resistance. Collectively, our findings indicate that sortilin controls adipose tissue fatty acid oxidation by substrate fuel selection during beige activation and provides a potentialnovel targeted approach for the treatment of metabolic diseases.
HostingRepository	iProX
AnnounceDate	2024-08-16
AnnouncementXML	Submission_2024-08-19_20:26:22.612.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Min Yang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-19 20:26:10	ID requested
⏵ 1	2024-08-19 20:26:22	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: Sortilin, ACSL1, thermogenesis

Contact List

Yong Chen
contact affiliation	Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
contact email	tj.y.chen@vip.163.com
lab head
Min Yang
contact affiliation	Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
contact email	yangmin420@vip.163.com
dataset submitter

Full Dataset Link List

iProX dataset URI