PXD054881-1

PXD054881 is an original dataset announced via ProteomeXchange.

Title	MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes
Description	MTCH2 is a protein localized in the outer membrane of mitochondria. It belongs to the solute carrier 25 family, but its substrates or transporter function remains unknown. Previous research links MTCH2 to apoptosis induction, and Alzheimer’s disease, mitochondrial metabolism and dynamics, and MTCH2 has been shown to function as a protein insertase and scramblase. Moreover, MTCH2 is a significant regulator of adipocyte differentiation and lipid homeostasis. Genome-wide association studies have identified MTCH2 variants to be associated with increased body mass index, obesity, and diabetes risk. Thus, MTCH2 emerges as a promising candidate for modulating adipocyte function and whole-body energy metabolism, but its specific metabolic role in mature adipose tissues remains unexplored. In this study, we show that MTCH2 regulates mitochondrial function and whole-body energy expenditure by regulating lipid utilization in adipose tissue.
HostingRepository	PRIDE
AnnounceDate	2025-07-20
AnnouncementXML	Submission_2025-07-19_18:00:27.342.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chunyan Wu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-14 04:11:43	ID requested
⏵ 1	2025-07-19 18:00:27	announced

Dataset with its publication pending

submitter keyword: mouse, brown adipocytes, DIA

Christian Wolfrum
contact affiliation	ETH Zürich, SLA, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
contact email	christian-wolfrum@ethz.ch
lab head
Chunyan Wu
contact affiliation	D-HEST, ETHZ
contact email	chunyan.wu@hest.ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD054881

PRIDE project URI

• PRIDE
  1. PXD054881
     1. Label: PRIDE project
     2. Name: MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes