PXD054747-1

PXD054747 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis of the SIRT1 activating compound SRT2104 effect on tibialis anterior muscle in Duchenne muscular dystrophy
Description	Duchenne muscular dystrophy (DMD) is a rare and devastating genetic disorder, whose management is still a major challenge, despite progress in genetic and pharmacological disease-modifying treatments have been made. Mitochondrial dysfunctions contribute to DMD, however, there are no effective mitochondrial therapies for DMD. SIRT1 is a NAD+-dependent class III histone deacetylase that controls several key processes and whose impairment is involved in determining mitochondrial dysfunction in DMD. In addition to well-known resveratrol, other potent selective activators of SIRT1 exist, with better pharmacokinetics properties. Among these, SRT2104 is the most promising and advanced in clinical studies. Here we evaluate the impact of SRT2104 in reshaping muscle proteome and acetylome profiles, highlighting the drug as an attractive exercise mimetic for the treatment of DMD. Overall, our data suggest SRT2104 as a possible therapeutic candidate to successfully counteract the progression of the dystrophic phenotype in DMD.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_00:25:44.665.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD054747
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Annapaola Andolfo
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-09 03:37:04	ID requested
⏵ 1	2025-05-07 00:25:45	announced

10.1038/s41419-025-07595-z;

Giovarelli M, Zecchini S, Casati SR, Lociuro L, Gjana O, Mollica L, Pisanu E, Mbissam HD, Cappellari O, De Santis C, Arcari A, Bigot A, Clerici G, Catalani E, Del Quondam S, Andolfo A, Braccia C, Cattaneo MG, Banfi C, Brunetti D, Mocciaro E, De Luca A, Clementi E, Cervia D, Perrotta C, De Palma C, The SIRT1 activator SRT2104 exerts exercise mimetic effects and promotes Duchenne muscular dystrophy recovery. Cell Death Dis, 16(1):259(2025) [pubmed]

10.6019/PXD054747;

submitter keyword: acetylome, mdx mice,Proteomics, Sirtuin 1, Duchenne muscular dystrophy

Clara De Palma
contact affiliation	Associate Professor of Pharmacology Dept of Medical Biotechnology and Translational Medicine Università degli Studi di Milano
contact email	clara.depalma@unimi.it
lab head
Annapaola Andolfo
contact affiliation	Ospedale San Raffaele
contact email	andolfo.annapaola@hsr.it
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD054747
     1. Label: PRIDE project
     2. Name: Proteomics analysis of the SIRT1 activating compound SRT2104 effect on tibialis anterior muscle in Duchenne muscular dystrophy