<<< Full experiment listing

PXD054717-3

PXD054717 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleImmune Proteins Recovered in Tooth Enamel as a Biochemical Record of Health in Past Populations
DescriptionThe enamel proteome includes a range of proteins which are well-preserved in archaeological settings but have so far received less study than the sex-specific sequencing of enamel. We look beyond sex-specific sequencing of amelogenin to investigate the potential of several serum proteins, including immunoglobulin gamma (IgG), the major immunoglobulin found in blood serum, and C-reactive protein (CRP) which is associated with inflammatory response, to provide insight into the health and stresses experienced by individuals in the past. We apply this approach to enamel samples from Mission-Period ancestral Ohlone interred at Asistencia San Pedro y San Pablo (CA-SMA-71/H; n=11). For comparison, we also examine enamel from historic-period European-Americans interred in the City Cemetery in San Francisco, and extracted third molars from present-day military cadets. Results indicate that IgG is elevated among individuals at the asistencia relative to samples from present-day military cadets (n=8), or historic City Cemetery individuals (ANOVA with post-hoc Tukey Kramer tests, p < 0.02). Further, the inflammatory protein CRP, normally expressed at much lower levels than IgG, was present in 55% (6 of 11) of the asistencia samples, and in 17% (2 of 12) of the historic City Cemetery samples, but was not detected in enamel samples from contemporary military cadets. While more studies are needed, we argue that the difference in IgG could reflect higher levels of chronic diseases such as tuberculosis among Ohlone living within the Mission system, while the presence of measurable amounts of CRP could relate to high degrees of physical, social, and emotional stresses. To our knowledge, this is the first paleoproteomic study of immune proteins in tooth enamel. The ability to track immune responses during tooth formation could provide valuable and high-resolution information on ancient health and disease at the level of the individual over archaeological time-scales.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_07:00:55.190.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTammy Buonasera
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; deamidated residue
InstrumentOrbitrap Exploris 480; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-08-08 08:31:18ID requested
12024-10-09 04:53:22announced
22024-10-09 06:25:09announced2024-10-09: Updated project metadata.
32024-10-22 07:00:55announced2024-10-22: Updated project metadata.
Publication List
10.1016/J.JAS.2024.106069;
Keyword List
submitter keyword: Archaeoproteomics, IgG,Paleoproteomics, C-Reactive Protein, Serum Albumin, Mission Period California, Tooth Enamel, Immune Proteins
Contact List
Tammy Buonasera
contact affiliationUniversity of Alaska Fairbanks, Department of Anthropology
contact emailtybuonasera@alaska.edu
lab head
Tammy Buonasera
contact affiliationUniversity of Alaska Fairbanks, University of California Davis
contact emailtybuonasera@alaska.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD054717
PRIDE project URI
Repository Record List
[ + ]