PXD054681-1

PXD054681 is an original dataset announced via ProteomeXchange.

Title	Deciphering Bhallataka Taila's Anticancer Potential in Lung Cancer Cells: Insights from a Proteomic Analysis
Description	Lung cancer remains the leading cause of cancer-related death worldwide due to its poor prognosis. Despite significant advancements in the understanding of cancer development, improvements in diagnostic methods, and multimodal therapeutic regimens, the prognosis of lung cancer has still not improved. Therefore, it is reasonable to look for newer and alternative medicines for treatment. Bhallataka nut extract, derived from the seeds of Semecarpus anacardium, was known to exhibit anti-inflammatory and antioxidant properties, suggesting potential as a treatment for cancer. In this study, we investigated the molecular networks associated with Bhallataka taila-mediated inhibition of lung adenocarcinoma. Treating lung cancer cell lines with Bhallataka taila resulted in decreased colony formation, proliferation, and migration, and increased apoptosis. A TMT based quantitative approach was used to identify the significantly altered proteins upon Bhallataka taila treatment at various timepoints. Gene Ontology (GO) analysis and pathway analysis was done for the significantly altered proteins and was later validated by immunoblotting.
HostingRepository	PRIDE
AnnounceDate	2024-12-21
AnnouncementXML	Submission_2024-12-21_03:47:35.622.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shobha Dagamajalu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-07 13:14:48	ID requested
⏵ 1	2024-12-21 03:47:35	announced

Dataset with its publication pending

submitter keyword: anticancer, temporal proteomics, therapeutic targets,Bhallataka taila, lung cancer

Dr. Shobha Dagamajalu
contact affiliation	Associate Professor Center for Systems Biology and Molecular Medicine Yenepoya Research Centre Yenepoya (Deemed to be University)
contact email	shobha_d@yenepoya.edu.in
lab head
Shobha Dagamajalu
contact affiliation	Associate Professor Center for Systems Biology and Molecular Medicine Yenepoya Research Centre Yenepoya (Deemed to be University)
contact email	shobha_d@yenepoya.edu.in
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD054681
     1. Label: PRIDE project
     2. Name: Deciphering Bhallataka Taila's Anticancer Potential in Lung Cancer Cells: Insights from a Proteomic Analysis