PXD054672-1

PXD054672 is an original dataset announced via ProteomeXchange.

Title	MS-based quantitative proteomic analysis of MAM from WT and obese mice.
Description	Diabetic cardiomyopathy (DCM) strongly leads to heart failure, notably with preserved ejection fraction (HFpEF). The involvement of mitochondria-associated reticular membranes (MAM) in T2D-related metabolic disorders starts to be demonstrated. In order to characterize the cardiac phenotype of an obesogenic type II diabetic mouse model (leptin-deficient ob/ob), we compared the proteome of its MAMs with those from WT mice.
HostingRepository	PRIDE
AnnounceDate	2025-06-16
AnnouncementXML	Submission_2025-06-15_16:06:59.909.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD054672
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yohann Couté
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-07 05:49:26	ID requested
⏵ 1	2025-06-15 16:07:00	announced

10.6019/PXD054672;

10.1016/j.jmccpl.2025.100453;

Guedouari H, Dia M, Geoffray J, Brun C, Moulin F, Givre L, Belmudes L, Leon C, Chanon S, Ji-Cao J, Chouabe C, Ducreux S, Crola Da Silva C, Gomez L, Cout, é Y, Thibault H, Rieusset J, Paillard M, mouse model. J Mol Cell Cardiol Plus, 12():100453(2025) [pubmed]

submitter keyword: mitochondria-associated reticular membranes (MAM),Mouse, obesity, diabetic cardiomyopathy, nanoLC-MS/MS

Yohann Couté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
lab head
Yohann Couté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD054672

PRIDE project URI

• PRIDE
  1. PXD054672
     1. Label: PRIDE project
     2. Name: MS-based quantitative proteomic analysis of MAM from WT and obese mice.