PXD054594 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mass spectrometry-based serum biomarker discovery from patients treated with an oncolytic adenovirus encoding TNFα and IL-2 (TILT-123): PROTEOMICS |
| Description | Oncolytic viruses represent an emerging therapeutic approach for treating patients with solid tumours. One such virus, TILT-123 (Ad5/3-E2F-D24-hTNFα-IRES-hIL-2), is a serotype chimeric oncolytic adenovirus. TILT-123 is designed to encode tumour necrosis factor alpha and interleukin-2, aiming to induce T-cell infiltration and cytotoxicity within solid tumours. After several years of preclinical development, TILT-123 is now tested in phase I clinical trials either as a monotherapy, or in combination with other T-cell therapies across various solid tumour types. In a single-arm, multicentre phase I dose-escalation trial TUNIMO (NCT04695327), the safety of TILT-123 in patients with advanced solid cancers refractory to standard therapy was evaluated. During the intravenous phase of the study, researchers collected patient serum to identify potential predictive biomarkers associated with intravenous delivery of TILT-123. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-05 |
| AnnouncementXML | Submission_2026-02-05_12:03:27.493.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD054594 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Sakari Joenväärä |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | carbamoylated residue; monohydroxylated residue |
| Instrument | Synapt MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-08-05 04:17:07 | ID requested | |
| ⏵ 1 | 2026-02-05 12:03:28 | announced | |
Publication List
Keyword List
| submitter keyword: oncolytic adenovirus, cancer, proteomics, UDMSE, solid tumor,Mass spectrometry |
Contact List
| Prof. Risto Renkonen |
|---|
| contact affiliation | 1. Translational Immunology Research Program, Transplantation Laboratory, University of Helsinki, Helsinki, Finland. 2. HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland |
| contact email | risto.renkonen@helsinki.fi |
| lab head | |
| Sakari Joenväärä |
|---|
| contact affiliation | Helsinki University |
| contact email | sakari.joenvaara@helsinki.fi |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD054594
- Label: PRIDE project
- Name: Mass spectrometry-based serum biomarker discovery from patients treated with an oncolytic adenovirus encoding TNFα and IL-2 (TILT-123): PROTEOMICS
