PXD054565-1
PXD054565 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Fraxetin targets PTGR2 to produce anti-inflammatory effects on the host and reduce the toxicity of Pseudomonas aeruginosa |
Description | Although the natural product fraxetin exhibits diverse biological functions, particularly in anti-inflammatory activities, its specific mechanism of action has remained unclear. Employing affinity-based protein profiling (AfBPP), prostaglandin reductase 2 (PTGR2), a key enzyme responsible for terminal inactivation of prostaglandins, is identified as the cellular target of fraxetin in host cells. Additionally, fraxetin is discovered to significantly reduce the production of pyoverdine in Pseudomonas aeruginosa, an essential virulence factor in its acute infections thereby protecting hosts from P. aeruginosa infection through anti-virulence mechanisms. Overall, our study elucidates the precise target of fraxetin and highlights the multifaceted nature of this bioactive natural product from both host and pathogen perspectives. |
HostingRepository | iProX |
AnnounceDate | 2024-08-04 |
AnnouncementXML | Submission_2024-08-05_00:20:36.284.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Songyao Kang |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Pseudomonas aeruginosa PAO1; NCBI TaxID: 208964; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-08-05 00:15:37 | ID requested | |
⏵ 1 | 2024-08-05 00:20:36 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Chemical Proteomics, Anti-inflammation, Pseudomonas aeruginosa, Virulence, Natural product |
Contact List
Weining Zhao | |
---|---|
contact affiliation | Shenzhen Technology University |
contact email | zhaoweining@sztu.edu.cn |
lab head | |
Songyao Kang | |
contact affiliation | Shenzhen Technology University |
contact email | 1490555176@qq.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |